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    <text><![CDATA[recognise the factors influencing the toxicity and effects of chemical substances on the human system]]></text>
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     <text><![CDATA[Toxicology has a reputation as the study of poisons, however a better definition is that "Toxicology is the study of adverse effects of chemicals on living organisms".]]></text>
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     <text><![CDATA[In toxicology, we determine the effects of natural and synthetic compounds on living things and seek an understanding of how the effects occur and what is the dose required to cause the effects.]]></text>
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		<p style="text-align:left;text-indent:0pt;margin:0pt 0pt 0pt 0pt;"><span style="color:#000000;background-color:transparent;font-family:'Trebuchet MS';font-size:14pt;font-weight:normal;font-style:normal;">Paracelsus, a 16</span><span style="color:#000000;background-color:transparent;font-family:'Trebuchet MS';font-size:10pt;font-weight:bold;font-style:normal;"><sup>th</sup></span><span style="color:#000000;background-color:transparent;font-family:'Trebuchet MS';font-size:14pt;font-weight:normal;font-style:normal;"> Century physician, declared:&nbsp;</span></p></body>
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     <text><![CDATA["All substances are poisons; there is none which is not a poison, the dose determines the poison. The right dose differentiates a poison and a remedy." ]]></text>
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     <text><![CDATA[A modern version of this statement would be:]]></text>
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     <text><![CDATA[The Risk is the probability of harm or injury occurring under the specific circumstances.]]></text>
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     <text><![CDATA[All chemical substances have the ability to cause health effects.  For different chemicals, health effects occur at different doses. ]]></text>
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     <text><![CDATA[Lethal doses:]]></text>
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     <text><![CDATA[Low toxicity                     High dose required]]></text>
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     <text><![CDATA[Caffeine                           in 100 cups of coffee]]></text>
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     <text><![CDATA[Salt                                 70 grams]]></text>
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     <text><![CDATA[High toxicity                    Low dose required]]></text>
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     <text><![CDATA[Botulinum                        0.7 micrograms]]></text>
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     <text><![CDATA[The dose (amount of chemical to which an individual is exposed) has a major influence on the adverse effect observed.  ]]></text>
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     <text><![CDATA[A classic way to describe the relationship between dose and effect is a dose-response curve.  As the dose increases the severity of effect increases.  ]]></text>
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     <text><![CDATA[This example shows the relationship between increasing the dose of blood alcohol and the adverse effects observed.  ]]></text>
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     <text><![CDATA[The value 0.05 translates to the legal limit for drinking and driving and it represents a dose which does not cause an adverse effect on the reaction times needed for driving. ]]></text>
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     <text><![CDATA[The dose required to cause an adverse effect is known as a 'threshold'.  ]]></text>
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     <text><![CDATA[Biological variability]]></text>
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     <text><![CDATA[The other factor which affects the adverse effect is the person himself!  ]]></text>
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     <text><![CDATA[Biological variability can be shown as the distribution of effect at the same dose within a population of individuals.  ]]></text>
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     <text><![CDATA[Some people's immune systems make them resistant to the effects of exposure. They are referred to as 'hyposensitive'.]]></text>
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     <text><![CDATA[Other people have extreme responses to exposure to a substance, and are called 'hypersensitive'.]]></text>
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     <text><![CDATA[However, most people will experience similar effects at the same dose. ]]></text>
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     <text><![CDATA[Biological variability can be influenced by age, sex, nutritional status, diseases, environmental factors and chemical interactions.]]></text>
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     <text><![CDATA[Additive - the combined effect = the sum of the effect of each substance]]></text>
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     <text><![CDATA[Synergistic - the combined effect > the sum of the individual components]]></text>
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     <text><![CDATA[Potentiation - a chemical with no specific effect makes another chemical more toxic  ]]></text>
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     <text><![CDATA[Antagonism - one chemical results in a reduction in the effect of the other chemical and is the basis of most antidotes.]]></text>
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     <text><![CDATA[Forms of toxic substances]]></text>
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     <text><![CDATA[The physical form of a substance can influence its toxicity significantly.]]></text>
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     <text><![CDATA[Highly volatile liquids can more easily result in exposure than non volatile liquids. ]]></text>
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     <text><![CDATA[Fumes - finely divided, heated particulate]]></text>
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    <action type="TEXTACTION" id="96" name="Smoke - combustion p" hasCondition="False">
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     <text><![CDATA[Smoke - combustion product; mix of forms]]></text>
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    <action type="TEXTACTION" id="97" name="Aerosols &amp;&amp; Mists -" hasCondition="False">
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     <text><![CDATA[Aerosols & Mists - suspended liquid droplets]]></text>
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    <action type="TEXTACTION" id="98" name="Vapours - gas phase" hasCondition="False">
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     <text><![CDATA[Vapours - gas phase above liquid]]></text>
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    <action type="TEXTACTION" id="99" name="Gases" hasCondition="False">
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     <backgroundSettings backgroundStyle="1" backgroundShape="0" backgroundColor="#FFFFFF" backgroundOpacity="100" gradientStartColor="#0000A0" gradientEndColor="#B8BBFF" gradientAngle="90" borderColor="#0000FF" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
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     <text><![CDATA[Gases]]></text>
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     <text><![CDATA[Solids]]></text>
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   <list type="INFORMATION" id="6-1" show="ALL">
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     <text><![CDATA[Toxicological effects: duration]]></text>
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     <text><![CDATA[There are two main types of toxicity that need to be considered when studying the adverse effects of chemicals.  ]]></text>
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     <text><![CDATA[These are acute and chronic toxicity: ]]></text>
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     <text><![CDATA[Acute effects:]]></text>
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     <text><![CDATA[occurring immediately or shortly after exposure ]]></text>
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     <text><![CDATA[usually from high concentration exposures but not necessarily so.]]></text>
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     <text><![CDATA[examples are mesothelioma caused by asbestos, and the effects of the salts of heavy metals such as mercury or lead which bioaccumulate in the body. ]]></text>
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   <correctAnswer><![CDATA[A|B]]></correctAnswer>
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     <text><![CDATA[Please click on the correct buttons and then click Next.]]></text>
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   <correctAnswer><![CDATA[B]]></correctAnswer>
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     <text><![CDATA[Exposure to a high concentration of a toxic substance will usually produce:]]></text>
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     <text><![CDATA[Toxicology is the study of adverse effects of chemicals on living organisms.]]></text>
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     <text><![CDATA[There is no such thing as a safe chemical only safe ways to handle chemicals.]]></text>
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     <text><![CDATA[Hazard - the intrinsic toxicological properties of the substance.]]></text>
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     <text><![CDATA[Risk - the probability of harm or injury under specific circumstances.]]></text>
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     <text><![CDATA[Toxicity is a measure of the hazard, i.e. a measure of the adverse effect exerted on the human body by a poisonous material.]]></text>
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     <text><![CDATA[The dose or amount of chemical to which an individual is exposed is a major factor on the influence of the adverse effect observed.]]></text>
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     <text><![CDATA[The other factor which affects the adverse effect is the person himself!  ]]></text>
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     <text><![CDATA[Within a population there are differences in the susceptibility among individuals to chemicals. ]]></text>
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     <text><![CDATA[The physical form of a substance can influence its toxicity significantly.]]></text>
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     <text><![CDATA[The effects that toxic substances can have can be acute or chronic. ]]></text>
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     <text><![CDATA[Injection - puncturing the skin.]]></text>
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     <text><![CDATA[The study of what the body does to chemical substances following exposure is called 'Toxicokinetics'.  ]]></text>
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     <text><![CDATA[More specifically, this involves the study of the absorption, distribution, metabolism and elimination of substances.]]></text>
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   <correctAnswer><![CDATA[B]]></correctAnswer>
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     <text><![CDATA[Which of the following best describes the sequence of events following exposure to a chemical?]]></text>
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     <text><![CDATA[Please click on the correct answer.]]></text>
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     <text><![CDATA[Biotransformation or metabolism of chemicals that enter the body will always result in that chemical being made less toxic.    ]]></text>
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     <text><![CDATA[Please click on the correct answer.]]></text>
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     <text><![CDATA[Please click on the correct buttons and then click Next.]]></text>
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      <text><![CDATA[Incorrect.  <br/><br/>Please try again.]]></text>
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      <text><![CDATA[Incorrect.  <br/><br/>The correct answer is (a) and (b).  <br/>]]></text>
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     <text><![CDATA[Remember]]></text>
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     <text><![CDATA[Chemical substances can enter the body through inhalation, absorption following skin or eye contact, by ingestion or swallowing, or occasionally by injection. ]]></text>
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     <text><![CDATA[Inhalation and skin absorption are the main exposure routes in the workplace.]]></text>
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     <text><![CDATA[The study of the absorption, distribution, metabolism and elimination of substances is called toxicokinetics.]]></text>
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     <text><![CDATA[Distribution - by the bloodstream and lymphatic system.]]></text>
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     <text><![CDATA[Metabolism - biotransformation of a substance into an excretable compound.]]></text>
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     <effectSettings fxEffect="0" effectDuration="0" hasShadow="False" shadowX="6" shadowY="6" shadowColor="#A9A9A9" shadowBlurRadius="10" />
     <text><![CDATA[Teratogenic - damage to developing embryo/foetus.]]></text>
     <textX>25</textX>
     <textY>0</textY>
     <textPosition>0</textPosition>
     <fontFamily>Trebuchet MS</fontFamily>
     <fontSize>19</fontSize>
     <textDecoration>none</textDecoration>
     <lineHeight>21</lineHeight>
     <fontStyle>Normal</fontStyle>
     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
     <fontHasShadow>False</fontHasShadow>
     <fontShadowColor>#808080</fontShadowColor>
     <fontShadowX>0</fontShadowX>
     <fontShadowY>0</fontShadowY>
     <fontShadowBlurRadius>0</fontShadowBlurRadius>
     <isPictureVisible>True</isPictureVisible>
     <pictureFileName width="20" height="18">bullet.bmp</pictureFileName>
     <picturePosition>0</picturePosition>
     <pictureX>0</pictureX>
     <pictureY>0</pictureY>
    </action>
    <action type="PAUSE" id="338" name="Wait for user" hasCondition="False">
     <waitMode>0</waitMode>
     <waitTime>0</waitTime>
     <timerValue>0</timerValue>
     <timerID>0</timerID>
     <cancelType>1</cancelType>
     <key1>none</key1>
     <key2 />
    </action>
   </list>
  </element>
  <element type="INFORMATION" id="21" elementName="Local or systemic effects" hasCondition="False" showInReference="True">
   <list type="INFORMATION" id="21-1" show="ALL">
    <action type="TEXTACTION" id="339" name="Local or systemic ef" hasCondition="False">
     <changeSettings isChangeAction="False" orginalID="339" changeID="-1" changedByID="-1" />
     <displaySettings left="598" top="43" width="279" height="30" isAddedToForeground="False" isAddedToBackground="False" isInitialVisible="True" />
     <backgroundSettings backgroundStyle="0" backgroundShape="0" backgroundColor="#000040" backgroundOpacity="100" gradientStartColor="#0000A0" gradientEndColor="#B8BBFF" gradientAngle="90" borderColor="#0000FF" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
     <effectSettings fxEffect="0" effectDuration="0" hasShadow="False" shadowX="6" shadowY="6" shadowColor="#A9A9A9" shadowBlurRadius="10" />
     <text><![CDATA[Local or systemic effects]]></text>
     <textX>0</textX>
     <textY>0</textY>
     <textPosition>4</textPosition>
     <fontFamily>Trebuchet MS</fontFamily>
     <fontSize>19</fontSize>
     <textDecoration>none</textDecoration>
     <lineHeight>21</lineHeight>
     <fontStyle>Normal</fontStyle>
     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
     <fontHasShadow>False</fontHasShadow>
     <fontShadowColor>#808080</fontShadowColor>
     <fontShadowX>0</fontShadowX>
     <fontShadowY>0</fontShadowY>
     <fontShadowBlurRadius>0</fontShadowBlurRadius>
     <isPictureVisible>False</isPictureVisible>
     <pictureFileName width="0" height="0" />
     <picturePosition>0</picturePosition>
     <pictureX>0</pictureX>
     <pictureY>0</pictureY>
    </action>
    <action type="SOUNDACTION" id="340" name="s15a.mp3" hasCondition="False">
     <mp3FileName>s15a.mp3</mp3FileName>
     <waitUntilComplete>False</waitUntilComplete>
     <cancelType>1</cancelType>
     <duration>42.057</duration>
    </action>
    <action type="IMAGEACTION" id="341" name="screen15.jpg" hasCondition="False">
     <changeSettings isChangeAction="False" orginalID="341" changeID="-1" changedByID="-1" />
     <displaySettings left="532" top="103" width="358" height="245" isAddedToForeground="False" isAddedToBackground="True" isInitialVisible="True" />
     <backgroundSettings backgroundStyle="1" backgroundShape="0" backgroundColor="transparent" backgroundOpacity="100" gradientStartColor="transparent" gradientEndColor="transparent" gradientAngle="90" borderColor="transparent" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
     <effectSettings fxEffect="0" effectDuration="0" hasShadow="False" shadowX="6" shadowY="6" shadowColor="#A9A9A9" shadowBlurRadius="10" />
     <allowFullScreen>False</allowFullScreen>
     <pictureFileName width="358" height="245">screen15.jpg</pictureFileName>
    </action>
    <action type="TEXTACTION" id="342" name="Toxic actions affect" hasCondition="False">
     <changeSettings isChangeAction="False" orginalID="342" changeID="-1" changedByID="-1" />
     <displaySettings left="29" top="103" width="384" height="48" isAddedToForeground="False" isAddedToBackground="False" isInitialVisible="True" />
     <backgroundSettings backgroundStyle="1" backgroundShape="0" backgroundColor="#FFFFFF" backgroundOpacity="100" gradientStartColor="#0000A0" gradientEndColor="#B8BBFF" gradientAngle="90" borderColor="#0000FF" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
     <effectSettings fxEffect="0" effectDuration="0" hasShadow="False" shadowX="6" shadowY="6" shadowColor="#A9A9A9" shadowBlurRadius="10" />
     <text><![CDATA[Toxic actions affecting the body's organs may be either localised or systemic.]]></text>
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     <textY>0</textY>
     <textPosition>0</textPosition>
     <fontFamily>Trebuchet MS</fontFamily>
     <fontSize>19</fontSize>
     <textDecoration>none</textDecoration>
     <lineHeight>21</lineHeight>
     <fontStyle>Normal</fontStyle>
     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
     <fontHasShadow>False</fontHasShadow>
     <fontShadowColor>#808080</fontShadowColor>
     <fontShadowX>0</fontShadowX>
     <fontShadowY>0</fontShadowY>
     <fontShadowBlurRadius>0</fontShadowBlurRadius>
     <isPictureVisible>False</isPictureVisible>
     <pictureFileName width="0" height="0" />
     <picturePosition>0</picturePosition>
     <pictureX>0</pictureX>
     <pictureY>0</pictureY>
    </action>
    <action type="PAUSE" id="343" name="Wait for 5.30000019073486 secs" hasCondition="False">
     <waitMode>1</waitMode>
     <waitTime>5.30000019073486</waitTime>
     <timerValue>0</timerValue>
     <timerID>0</timerID>
     <cancelType>1</cancelType>
     <key1>none</key1>
     <key2 />
    </action>
    <action type="TEXTACTION" id="344" name="Damage to eyes:" hasCondition="False">
     <changeSettings isChangeAction="False" orginalID="344" changeID="-1" changedByID="-1" />
     <displaySettings left="29" top="161" width="164" height="24" isAddedToForeground="False" isAddedToBackground="False" isInitialVisible="True" />
     <backgroundSettings backgroundStyle="1" backgroundShape="0" backgroundColor="#FFFFFF" backgroundOpacity="100" gradientStartColor="#0000A0" gradientEndColor="#B8BBFF" gradientAngle="90" borderColor="#0000FF" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
     <effectSettings fxEffect="0" effectDuration="0" hasShadow="False" shadowX="6" shadowY="6" shadowColor="#A9A9A9" shadowBlurRadius="10" />
     <text><![CDATA[Damage to eyes: ]]></text>
     <textX>0</textX>
     <textY>0</textY>
     <textPosition>0</textPosition>
     <fontFamily>Trebuchet MS</fontFamily>
     <fontSize>19</fontSize>
     <textDecoration>none</textDecoration>
     <lineHeight>21</lineHeight>
     <fontStyle>Normal</fontStyle>
     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
     <fontHasShadow>False</fontHasShadow>
     <fontShadowColor>#808080</fontShadowColor>
     <fontShadowX>0</fontShadowX>
     <fontShadowY>0</fontShadowY>
     <fontShadowBlurRadius>0</fontShadowBlurRadius>
     <isPictureVisible>False</isPictureVisible>
     <pictureFileName width="0" height="0" />
     <picturePosition>0</picturePosition>
     <pictureX>0</pictureX>
     <pictureY>0</pictureY>
    </action>
    <action type="TEXTACTION" id="345" name="Localised due to dir" hasCondition="False">
     <changeSettings isChangeAction="False" orginalID="345" changeID="-1" changedByID="-1" />
     <displaySettings left="29" top="195" width="400" height="50" isAddedToForeground="False" isAddedToBackground="False" isInitialVisible="True" />
     <backgroundSettings backgroundStyle="1" backgroundShape="0" backgroundColor="#FFFFFF" backgroundOpacity="100" gradientStartColor="#0000A0" gradientEndColor="#B8BBFF" gradientAngle="90" borderColor="#0000FF" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
     <effectSettings fxEffect="0" effectDuration="0" hasShadow="False" shadowX="6" shadowY="6" shadowColor="#A9A9A9" shadowBlurRadius="10" />
     <text><![CDATA[Localised due to direct contact, causing irritation, corrosion or tears (lachrymation) ]]></text>
     <textX>25</textX>
     <textY>0</textY>
     <textPosition>0</textPosition>
     <fontFamily>Trebuchet MS</fontFamily>
     <fontSize>19</fontSize>
     <textDecoration>none</textDecoration>
     <lineHeight>21</lineHeight>
     <fontStyle>Normal</fontStyle>
     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
     <fontHasShadow>False</fontHasShadow>
     <fontShadowColor>#808080</fontShadowColor>
     <fontShadowX>0</fontShadowX>
     <fontShadowY>0</fontShadowY>
     <fontShadowBlurRadius>0</fontShadowBlurRadius>
     <isPictureVisible>True</isPictureVisible>
     <pictureFileName width="20" height="18">bullet.bmp</pictureFileName>
     <picturePosition>0</picturePosition>
     <pictureX>0</pictureX>
     <pictureY>0</pictureY>
    </action>
    <action type="PAUSE" id="346" name="Wait for 8.69999980926514 secs" hasCondition="False">
     <waitMode>1</waitMode>
     <waitTime>8.69999980926514</waitTime>
     <timerValue>0</timerValue>
     <timerID>0</timerID>
     <cancelType>1</cancelType>
     <key1>none</key1>
     <key2 />
    </action>
    <action type="TEXTACTION" id="347" name="Systemic by absorpti" hasCondition="False">
     <changeSettings isChangeAction="False" orginalID="347" changeID="-1" changedByID="-1" />
     <displaySettings left="29" top="255" width="389" height="50" isAddedToForeground="False" isAddedToBackground="False" isInitialVisible="True" />
     <backgroundSettings backgroundStyle="1" backgroundShape="0" backgroundColor="#FFFFFF" backgroundOpacity="100" gradientStartColor="#0000A0" gradientEndColor="#B8BBFF" gradientAngle="90" borderColor="#0000FF" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
     <effectSettings fxEffect="0" effectDuration="0" hasShadow="False" shadowX="6" shadowY="6" shadowColor="#A9A9A9" shadowBlurRadius="10" />
     <text><![CDATA[Systemic by absorption causing blindness or cataracts.]]></text>
     <textX>25</textX>
     <textY>0</textY>
     <textPosition>0</textPosition>
     <fontFamily>Trebuchet MS</fontFamily>
     <fontSize>19</fontSize>
     <textDecoration>none</textDecoration>
     <lineHeight>21</lineHeight>
     <fontStyle>Normal</fontStyle>
     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
     <fontHasShadow>False</fontHasShadow>
     <fontShadowColor>#808080</fontShadowColor>
     <fontShadowX>0</fontShadowX>
     <fontShadowY>0</fontShadowY>
     <fontShadowBlurRadius>0</fontShadowBlurRadius>
     <isPictureVisible>True</isPictureVisible>
     <pictureFileName width="20" height="18">bullet.bmp</pictureFileName>
     <picturePosition>0</picturePosition>
     <pictureX>0</pictureX>
     <pictureY>0</pictureY>
    </action>
    <action type="PAUSE" id="348" name="Wait for 8 secs" hasCondition="False">
     <waitMode>1</waitMode>
     <waitTime>8</waitTime>
     <timerValue>0</timerValue>
     <timerID>0</timerID>
     <cancelType>1</cancelType>
     <key1>none</key1>
     <key2 />
    </action>
    <action type="TEXTACTION" id="349" name="Ingestion:" hasCondition="False">
     <changeSettings isChangeAction="False" orginalID="349" changeID="-1" changedByID="-1" />
     <displaySettings left="29" top="319" width="96" height="24" isAddedToForeground="False" isAddedToBackground="False" isInitialVisible="True" />
     <backgroundSettings backgroundStyle="1" backgroundShape="0" backgroundColor="#FFFFFF" backgroundOpacity="100" gradientStartColor="#0000A0" gradientEndColor="#B8BBFF" gradientAngle="90" borderColor="#0000FF" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
     <effectSettings fxEffect="0" effectDuration="0" hasShadow="False" shadowX="6" shadowY="6" shadowColor="#A9A9A9" shadowBlurRadius="10" />
     <text><![CDATA[Ingestion:]]></text>
     <textX>0</textX>
     <textY>0</textY>
     <textPosition>0</textPosition>
     <fontFamily>Trebuchet MS</fontFamily>
     <fontSize>19</fontSize>
     <textDecoration>none</textDecoration>
     <lineHeight>21</lineHeight>
     <fontStyle>Normal</fontStyle>
     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
     <fontHasShadow>False</fontHasShadow>
     <fontShadowColor>#808080</fontShadowColor>
     <fontShadowX>0</fontShadowX>
     <fontShadowY>0</fontShadowY>
     <fontShadowBlurRadius>0</fontShadowBlurRadius>
     <isPictureVisible>False</isPictureVisible>
     <pictureFileName width="0" height="0" />
     <picturePosition>0</picturePosition>
     <pictureX>0</pictureX>
     <pictureY>0</pictureY>
    </action>
    <action type="TEXTACTION" id="350" name="Localised effects su" hasCondition="False">
     <changeSettings isChangeAction="False" orginalID="350" changeID="-1" changedByID="-1" />
     <displaySettings left="29" top="353" width="376" height="47" isAddedToForeground="False" isAddedToBackground="False" isInitialVisible="True" />
     <backgroundSettings backgroundStyle="1" backgroundShape="0" backgroundColor="#FFFFFF" backgroundOpacity="100" gradientStartColor="#0000A0" gradientEndColor="#B8BBFF" gradientAngle="90" borderColor="#0000FF" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
     <effectSettings fxEffect="0" effectDuration="0" hasShadow="False" shadowX="6" shadowY="6" shadowColor="#A9A9A9" shadowBlurRadius="10" />
     <text><![CDATA[Localised effects such as corrosion or irritation ]]></text>
     <textX>25</textX>
     <textY>0</textY>
     <textPosition>0</textPosition>
     <fontFamily>Trebuchet MS</fontFamily>
     <fontSize>19</fontSize>
     <textDecoration>none</textDecoration>
     <lineHeight>21</lineHeight>
     <fontStyle>Normal</fontStyle>
     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
     <fontHasShadow>False</fontHasShadow>
     <fontShadowColor>#808080</fontShadowColor>
     <fontShadowX>0</fontShadowX>
     <fontShadowY>0</fontShadowY>
     <fontShadowBlurRadius>0</fontShadowBlurRadius>
     <isPictureVisible>True</isPictureVisible>
     <pictureFileName width="20" height="18">bullet.bmp</pictureFileName>
     <picturePosition>0</picturePosition>
     <pictureX>0</pictureX>
     <pictureY>0</pictureY>
    </action>
    <action type="PAUSE" id="351" name="Wait for 4.29999923706055 secs" hasCondition="False">
     <waitMode>1</waitMode>
     <waitTime>4.29999923706055</waitTime>
     <timerValue>0</timerValue>
     <timerID>0</timerID>
     <cancelType>1</cancelType>
     <key1>none</key1>
     <key2 />
    </action>
    <action type="TEXTACTION" id="352" name="Systemic effects by" hasCondition="False">
     <changeSettings isChangeAction="False" orginalID="352" changeID="-1" changedByID="-1" />
     <displaySettings left="29" top="410" width="743" height="48" isAddedToForeground="False" isAddedToBackground="False" isInitialVisible="True" />
     <backgroundSettings backgroundStyle="1" backgroundShape="0" backgroundColor="#FFFFFF" backgroundOpacity="100" gradientStartColor="#0000A0" gradientEndColor="#B8BBFF" gradientAngle="90" borderColor="#0000FF" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
     <effectSettings fxEffect="0" effectDuration="0" hasShadow="False" shadowX="6" shadowY="6" shadowColor="#A9A9A9" shadowBlurRadius="10" />
     <text><![CDATA[Systemic effects by absorption along the entire gastrointestinal tract. Absorption depends on pH, molecular size and chemical nature. ]]></text>
     <textX>25</textX>
     <textY>0</textY>
     <textPosition>0</textPosition>
     <fontFamily>Trebuchet MS</fontFamily>
     <fontSize>19</fontSize>
     <textDecoration>none</textDecoration>
     <lineHeight>21</lineHeight>
     <fontStyle>Normal</fontStyle>
     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
     <fontHasShadow>False</fontHasShadow>
     <fontShadowColor>#808080</fontShadowColor>
     <fontShadowX>0</fontShadowX>
     <fontShadowY>0</fontShadowY>
     <fontShadowBlurRadius>0</fontShadowBlurRadius>
     <isPictureVisible>True</isPictureVisible>
     <pictureFileName width="20" height="18">bullet.bmp</pictureFileName>
     <picturePosition>0</picturePosition>
     <pictureX>0</pictureX>
     <pictureY>0</pictureY>
    </action>
    <action type="PAUSE" id="353" name="Wait for user" hasCondition="False">
     <waitMode>0</waitMode>
     <waitTime>0</waitTime>
     <timerValue>0</timerValue>
     <timerID>0</timerID>
     <cancelType>1</cancelType>
     <key1>none</key1>
     <key2 />
    </action>
   </list>
  </element>
  <element type="INFORMATION" id="22" elementName="Local or systemic effects" hasCondition="False" showInReference="True">
   <list type="INFORMATION" id="22-1" show="ALL">
    <action type="TEXTACTION" id="354" name="Local or systemic ef" hasCondition="False">
     <changeSettings isChangeAction="False" orginalID="354" changeID="-1" changedByID="-1" />
     <displaySettings left="598" top="43" width="279" height="30" isAddedToForeground="False" isAddedToBackground="False" isInitialVisible="True" />
     <backgroundSettings backgroundStyle="0" backgroundShape="0" backgroundColor="#000040" backgroundOpacity="100" gradientStartColor="#0000A0" gradientEndColor="#B8BBFF" gradientAngle="90" borderColor="#0000FF" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
     <effectSettings fxEffect="0" effectDuration="0" hasShadow="False" shadowX="6" shadowY="6" shadowColor="#A9A9A9" shadowBlurRadius="10" />
     <text><![CDATA[Local or systemic effects]]></text>
     <textX>0</textX>
     <textY>0</textY>
     <textPosition>4</textPosition>
     <fontFamily>Trebuchet MS</fontFamily>
     <fontSize>19</fontSize>
     <textDecoration>none</textDecoration>
     <lineHeight>21</lineHeight>
     <fontStyle>Normal</fontStyle>
     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
     <fontHasShadow>False</fontHasShadow>
     <fontShadowColor>#808080</fontShadowColor>
     <fontShadowX>0</fontShadowX>
     <fontShadowY>0</fontShadowY>
     <fontShadowBlurRadius>0</fontShadowBlurRadius>
     <isPictureVisible>False</isPictureVisible>
     <pictureFileName width="0" height="0" />
     <picturePosition>0</picturePosition>
     <pictureX>0</pictureX>
     <pictureY>0</pictureY>
    </action>
    <action type="SOUNDACTION" id="355" name="s15b.mp3" hasCondition="False">
     <mp3FileName>s15b.mp3</mp3FileName>
     <waitUntilComplete>False</waitUntilComplete>
     <cancelType>1</cancelType>
     <duration>40.777</duration>
    </action>
    <action type="TEXTACTION" id="356" name="Skin effects:" hasCondition="False">
     <changeSettings isChangeAction="False" orginalID="356" changeID="-1" changedByID="-1" />
     <displaySettings left="27" top="104" width="123" height="24" isAddedToForeground="False" isAddedToBackground="False" isInitialVisible="True" />
     <backgroundSettings backgroundStyle="1" backgroundShape="0" backgroundColor="#FFFFFF" backgroundOpacity="100" gradientStartColor="#0000A0" gradientEndColor="#B8BBFF" gradientAngle="90" borderColor="#0000FF" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
     <effectSettings fxEffect="0" effectDuration="0" hasShadow="False" shadowX="6" shadowY="6" shadowColor="#A9A9A9" shadowBlurRadius="10" />
     <text><![CDATA[Skin effects:]]></text>
     <textX>0</textX>
     <textY>0</textY>
     <textPosition>0</textPosition>
     <fontFamily>Trebuchet MS</fontFamily>
     <fontSize>19</fontSize>
     <textDecoration>none</textDecoration>
     <lineHeight>21</lineHeight>
     <fontStyle>Normal</fontStyle>
     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
     <fontHasShadow>False</fontHasShadow>
     <fontShadowColor>#808080</fontShadowColor>
     <fontShadowX>0</fontShadowX>
     <fontShadowY>0</fontShadowY>
     <fontShadowBlurRadius>0</fontShadowBlurRadius>
     <isPictureVisible>False</isPictureVisible>
     <pictureFileName width="0" height="0" />
     <picturePosition>0</picturePosition>
     <pictureX>0</pictureX>
     <pictureY>0</pictureY>
    </action>
    <action type="TEXTACTION" id="357" name="Localised irritation" hasCondition="False">
     <changeSettings isChangeAction="False" orginalID="357" changeID="-1" changedByID="-1" />
     <displaySettings left="27" top="138" width="404" height="47" isAddedToForeground="False" isAddedToBackground="False" isInitialVisible="True" />
     <backgroundSettings backgroundStyle="1" backgroundShape="0" backgroundColor="#FFFFFF" backgroundOpacity="100" gradientStartColor="#0000A0" gradientEndColor="#B8BBFF" gradientAngle="90" borderColor="#0000FF" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
     <effectSettings fxEffect="0" effectDuration="0" hasShadow="False" shadowX="6" shadowY="6" shadowColor="#A9A9A9" shadowBlurRadius="10" />
     <text><![CDATA[Localised irritation, corrosion or burns and sensitisation]]></text>
     <textX>25</textX>
     <textY>0</textY>
     <textPosition>0</textPosition>
     <fontFamily>Trebuchet MS</fontFamily>
     <fontSize>19</fontSize>
     <textDecoration>none</textDecoration>
     <lineHeight>21</lineHeight>
     <fontStyle>Normal</fontStyle>
     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
     <fontHasShadow>False</fontHasShadow>
     <fontShadowColor>#808080</fontShadowColor>
     <fontShadowX>0</fontShadowX>
     <fontShadowY>0</fontShadowY>
     <fontShadowBlurRadius>0</fontShadowBlurRadius>
     <isPictureVisible>True</isPictureVisible>
     <pictureFileName width="20" height="18">bullet.bmp</pictureFileName>
     <picturePosition>0</picturePosition>
     <pictureX>0</pictureX>
     <pictureY>0</pictureY>
    </action>
    <action type="PAUSE" id="358" name="Wait for 6.40000009536743 secs" hasCondition="False">
     <waitMode>1</waitMode>
     <waitTime>6.40000009536743</waitTime>
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     <timerID>0</timerID>
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    </action>
    <action type="TEXTACTION" id="359" name="Systemic absorption" hasCondition="False">
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     <text><![CDATA[Systemic absorption depends on the lipid or fat solubility of the body towards the substance, skin thickness, open wounds and duration of the exposure.]]></text>
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    <action type="PAUSE" id="360" name="Wait for 11.8999991416931 secs" hasCondition="False">
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    </action>
    <action type="TEXTACTION" id="361" name="Respiratory effects:" hasCondition="False">
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     <text><![CDATA[Respiratory effects:]]></text>
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     <text><![CDATA[Large dust particles are filtered out by the nose or the trachea, then swallowed or exhaled]]></text>
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     <text><![CDATA[Fine dust particles and insoluble gases reaching the lungs can enter the blood stream or cause damage to the lungs]]></text>
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     <text><![CDATA[Inhalation is usually the quickest route of exposure to toxic substances.]]></text>
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   <list type="INFORMATION" id="23-1" show="ALL">
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    <action type="SOUNDACTION" id="369" name="please_answer.mp3" hasCondition="False">
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    <action type="TEXTACTION" id="370" name="Self-assessment" hasCondition="False">
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     <text><![CDATA[Self-assessment]]></text>
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    <action type="TEXTACTION" id="371" name="Link the type of tox" hasCondition="False">
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     <text><![CDATA[Link the type of toxic action with the correct description]]></text>
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     <text><![CDATA[Description]]></text>
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    <action type="TEXTACTION" id="373" name="Type of action" hasCondition="False">
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     <text><![CDATA[Type of action]]></text>
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    <action type="TEXTACTION" id="374" name="Tissue inflammation" hasCondition="False">
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     <text><![CDATA[Tissue inflammation]]></text>
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     <text><![CDATA[Displaces oxygen]]></text>
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     <text><![CDATA[Causes cancer]]></text>
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     <text><![CDATA[Causes hereditary defects]]></text>
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     <text><![CDATA[Damages developing embryo]]></text>
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    <action type="TEXTACTION" id="381" name="Untitled" hasCondition="False">
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     <backgroundSettings backgroundStyle="0" backgroundShape="0" backgroundColor="#FFFFFF" backgroundOpacity="100" gradientStartColor="#0000A0" gradientEndColor="#B8BBFF" gradientAngle="90" borderColor="#01D4D4" borderType="0" borderWidth="2" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
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     <fontStyle>Normal</fontStyle>
     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
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    <action type="TEXTACTION" id="382" name="Untitled" hasCondition="False">
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     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
     <fontHasShadow>False</fontHasShadow>
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     <fontWeight>Normal</fontWeight>
     <fontColor>#000000</fontColor>
     <autoRefresh>False</autoRefresh>
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     <isPictureVisible>False</isPictureVisible>
     <pictureFileName width="0" height="0" />
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     <text><![CDATA[Please drag the type of action into the boxes, then click Next.]]></text>
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     <value>A</value>
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     <text><![CDATA[]]></text>
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     <value>C</value>
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     <value>D</value>
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     <text><![CDATA[]]></text>
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      <text><![CDATA[Incorrect.<br/><br/>The correct answers are shown.]]></text>
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      <backgroundSettings backgroundStyle="1" backgroundShape="0" backgroundColor="transparent" backgroundOpacity="100" gradientStartColor="transparent" gradientEndColor="transparent" gradientAngle="90" borderColor="transparent" borderType="0" borderWidth="0" radiusX="15" radiusY="15" contentMarginLeft="0" contentMarginRight="0" contentMarginTop="0" contentMarginBottom="0" />
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     <text><![CDATA[Hazardous substances can cause several types of toxic action on the body including:]]></text>
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     <text><![CDATA[Asphyxiant - displaces or interferes with oxygen utilisation]]></text>
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     <text><![CDATA[Mutagenic - damage to cellular genetic material causing hereditary effects]]></text>
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     <text><![CDATA[used to determine the effect of substances on cell cultures in laboratory glassware.]]></text>
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     <text><![CDATA[give a better indication of what will happen when a substance is administered]]></text>
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<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:14pt;">LD</span><span style="font-family:'Trebuchet MS';font-size:8pt;"><b>50</b></span><span style="font-family:'Trebuchet MS';font-size:14pt;">: dose lethal (oral or skin contact) to 50% of animals in a test group&nbsp;</span></p></body>]]></html>
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<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:14pt;">LD</span><span style="font-family:'Trebuchet MS';font-size:8pt;"><b>50</b></span><span style="font-family:'Trebuchet MS';font-size:14pt;">: concentration (inhalation) lethal to 50% of animals in a test group&nbsp;</span></p></body>]]></html>
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     <text><![CDATA[NOHSC 1008 (2004) lists 68 Risk Phrases, many of which relate to substances associated with health hazards.]]></text>
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     <text><![CDATA[E.g. very toxic by inhalation R26, very toxic by skin contact R27 or very toxic by swallowing R28. ]]></text>
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     <text><![CDATA[Some risk phrases describe danger to humans or the environment.]]></text>
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     <text><![CDATA[Substances or mixtures can have more than one health affect. ]]></text>
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     <text><![CDATA[The NOHSC Standard 1008 (2004) describes concentration limits to be used in the evaluation of health hazards.]]></text>
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     <text><![CDATA[It classifies single ingredients or mixtures which can include solids, liquids and gas or vapour mixtures.]]></text>
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     <text><![CDATA[Tables show concentrations by weight of ingredients that are considered very toxic, toxic or harmful according to the relevant risk phrases. ]]></text>
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     <text><![CDATA[Note that a low concentration of a very toxic ingredient may only be described as harmful.]]></text>
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   <correctAnswer><![CDATA[A|B]]></correctAnswer>
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     <text><![CDATA[Please click on the correct buttons and then click Next.]]></text>
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     <text><![CDATA[Toxicity data can be obtained from both animal and non-animal testing.]]></text>
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		<p style="text-align:left;text-indent:0pt;margin:0pt 0pt 0pt 0pt;"><span style="color:#000000;background-color:transparent;font-family:'Trebuchet MS';font-size:14pt;font-weight:normal;font-style:normal;">An LD</span><span style="color:#000000;background-color:transparent;font-family:'Trebuchet MS';font-size:8pt;font-weight:bold;font-style:normal;">50</span><span style="color:#000000;background-color:transparent;font-family:'Trebuchet MS';font-size:14pt;font-weight:normal;font-style:normal;"> is the dose lethal to 50% of animals in a test group. &nbsp;</span></p></body>
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]]></html>
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     <text><![CDATA[The outcomes of toxicity testing are standardised, and classification schemes have been created to categorise the adverse effects of chemicals.]]></text>
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     <text><![CDATA[6.1.5 Material safety data]]></text>
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     <text><![CDATA[Some occupational toxins]]></text>
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     <text><![CDATA[In the coatings and related industries, workers may potentially be exposed to a wide variety of occupational toxins, if suitable precautions are not taken.]]></text>
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     <text><![CDATA[Some examples of hazardous materials present in the industry are shown on your screen.]]></text>
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     <text><![CDATA[It must be noted that not all chemicals used in industry are toxic, and also that the list shown is not meant to be exhaustive. ]]></text>
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     <text><![CDATA[Workers should always refer to the Material Safety Data Sheet to confirm whether a substance is hazardous.]]></text>
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     <text><![CDATA[Material Safety Data Sheet]]></text>
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     <text><![CDATA[The manufacturer or importer of a substance is responsible for determining whether or not it is hazardous, and is therefore responsible for producing the MSDS. ]]></text>
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     <text><![CDATA[MSDS are used internationally although their format varies.  In Australia, the MSDS must comply with the National Code of Practice for the Preparation of Material Safety Data Sheets (NOHSC:2011(1994)). ]]></text>
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     <text><![CDATA[Eight part NOHSC format includes the following major information:]]></text>
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<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;"><b>1. Introductory Details</b></span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;">    - Statement of hazardous nature, Date of Issue</span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;"><b>2. Company Details and Contact Numbers</b></span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;"><b>3. Identification</b></span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;">    - Product description</span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;">    - Physical properties</span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;">    - Ingredients by proportion, name and CAS number</span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;"><b>4. Health Hazard Information</b></span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;"><b>    </b></span><span style="font-family:'Trebuchet MS';font-size:10pt;">- Acute/chronic effects, First Aid, Advice to Doctor</span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;"><b>6. Precautions for Use</b></span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;"><b>   </b></span><span style="font-family:'Trebuchet MS';font-size:10pt;"> - Exposure Standards, Personal Protection</span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;"><b>7. Safe Handling Information</b></span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;"><b>    </b></span><span style="font-family:'Trebuchet MS';font-size:10pt;">- Storage and Transport, Spills and Disposal, Emergency Contact Point</span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;"><b>8. Other Information</b></span></p>
<p style='margin-top:0pt;margin-bottom:0pt;'><span style="font-family:'Trebuchet MS';font-size:10pt;"><b>    </b></span><span style="font-family:'Trebuchet MS';font-size:10pt;">- Toxicity and Ecotoxicity, Biodegradability, Persistence in Soil/Water&nbsp;</span></p></body>]]></html>
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     <text><![CDATA[patterns of illness or discomfort.]]></text>
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     <text><![CDATA[For further information see 'Guidance Note for the Assessment of Health Risks arising from the Use of Hazardous Substances in the Workplace' [NOHSC:3017(1994)] which may be downloaded from the NOHSC website.]]></text>
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     <text><![CDATA[Legislation requires that the user of a material is responsible for producing a Material Safety Data Sheet.  ]]></text>
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     <text><![CDATA[Please click on the correct answer.]]></text>
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     </action>
    </list>
   </response>
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    <condition filter="----" forResponse="True" attempt="0">
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    </condition>
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      <text><![CDATA[Correct.]]></text>
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      <text><![CDATA[Incorrect. <br/><br/>The statement is False.]]></text>
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   <correctAnswer><![CDATA[C]]></correctAnswer>
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     <text><![CDATA[Please click on the correct checkbox, then click Next.]]></text>
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     <text><![CDATA[Date of issue]]></text>
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    <action type="TEXTACTION" id="672" name="Health hazard inform" hasCondition="False">
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    <action type="TEXTACTION" id="675" name="Personal protection" hasCondition="False">
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     <text><![CDATA[Workers should always refer to the Material Safety Data Sheet to confirm whether a substance is hazardous.]]></text>
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     <text><![CDATA[6.1.6 Monitoring && exposure standards]]></text>
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     <text><![CDATA[where it is necessary to obtain a quantitative estimate of exposure ]]></text>
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     <text><![CDATA[or to determine the effectiveness of measures introduced to control exposure.]]></text>
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     <text><![CDATA[Procedures for sampling are laid down in the National Code of Practice for the Control of Workplace Hazardous Substances [NOHSC:2007(1994)] and include: ]]></text>
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     <text><![CDATA[the sites and frequency of sampling]]></text>
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<p style="margin-top: 5pt;margin-bottom: 5pt;"><span style="font-family:'Trebuchet MS';font-size:13pt;">Biological Exposure Indices (BEIs</span><span style="font-family:'Symbol';font-size:11pt;"><sup>&Ograve;</SUP></span><span style="font-family:'Trebuchet MS';font-size:13pt;">): </span><span style="font-family:'Trebuchet MS';font-size:14pt;">  &nbsp;</span></p></body>]]></html>
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     <text><![CDATA[In most cases the specimen used for biological monitoring is urine, blood or exhaled air]]></text>
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     <text><![CDATA[BEIs are not intended for use as a measure of adverse effects or for diagnosis of occupational illness ]]></text>
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     <text><![CDATA[Personal air monitoring techniques include devices capable of collecting dusts, metal fumes, vapours and gases which can then be analysed for type and the quantity to which a worker is exposed over a timed period. ]]></text>
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     <text><![CDATA[For further information see U.S. Department of Labor Occupational Health and Safety Technical Manual, Section II, Sampling and Measurement Methods and Instruments. ]]></text>
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     <text><![CDATA[Exposure Standard means an airborne concentration of a particular substance in the worker's breathing zone, which according to current knowledge, should not cause adverse health effects to nearly all workers.]]></text>
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     <text><![CDATA[It may also be referred to as the Threshold Limit Value or TLV. ]]></text>
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     <text><![CDATA[Exposure standards can be in three forms: ]]></text>
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     <text><![CDATA[(Referenced from NOHSC Guidance Material for the Hazardous Substances Information System - Exposure Standards Data Set)]]></text>
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     <text><![CDATA[The Australian Government Hazardous Substance Information System is an internet database that allows you to find hazardous substance information and exposure standard information. ]]></text>
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     <text><![CDATA[Both data sets can be searched using a range of search criteria. ]]></text>
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     <text><![CDATA[Other considerations such as economic, social or technological implications or sampling and analytical limitations need to be taken into account when interpreting results. ]]></text>
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     <text><![CDATA[Exposure standards are not fine dividing lines between safe and unsafe exposures, are not measures of relative toxicity and do not protect all workers. ]]></text>
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     <text><![CDATA[For further information see the HSIS User Instruction Manual on the NOHSC website.]]></text>
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     <text><![CDATA[Please click on the correct buttons and then click Next.]]></text>
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     <text><![CDATA[Biological Exposure Indices should be used to diagnose occupational illnesses.]]></text>
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      <text><![CDATA[Incorrect.  <br/><br/>Please try again.]]></text>
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      <text><![CDATA[Incorrect.  <br/><br/>The correct answer is (b) and (c).  <br/>]]></text>
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     <text><![CDATA[Procedures for sampling are laid down in the National Code of Practice for the Control of Workplace Hazardous Substances.]]></text>
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     <text><![CDATA[It entails measurement of the concentration of a chemical in the blood or urine of people exposed, and is an indicator of the uptake of a substance.]]></text>
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     <text><![CDATA[Air monitoring may be personal, to estimate individual worker exposure, or environmental, to determine or select workplace control methods.]]></text>
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     <text><![CDATA[Toxicity is a measure of the hazard, i.e. a measure of the adverse effect exerted on the human body by a poisonous material.]]></text>
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     <text><![CDATA[The dose or amount of chemical to which an individual is exposed is a major factor on the influence of the adverse effect observed.]]></text>
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     <text><![CDATA[The other factor which affects the adverse effect is the person himself!  ]]></text>
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     <text><![CDATA[Within a population there are differences in the susceptibility among individuals to chemicals. ]]></text>
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     <text><![CDATA[Biological variability can be shown as the distribution of effect at the same dose within a population of individuals.  ]]></text>
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     <text><![CDATA[Some people will be very sensitive (hypersensitive), and others tolerant (hyposensitive). ]]></text>
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     <text><![CDATA[Biological variability can be influenced by age, sex, nutritional status, diseases, environmental factors and chemical interactions.]]></text>
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     <text><![CDATA[The physical form of a substance can influence its toxicity significantly.]]></text>
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     <text><![CDATA[The effects that toxic substances can have can be acute or chronic. ]]></text>
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     <text><![CDATA[Toxicological effects can be reversible or irreversible, and localised or systemic.]]></text>
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     <text><![CDATA[Chemical substances can enter the body through inhalation, absorption following skin or eye contact, by ingestion or swallowing, or occasionally by injection. ]]></text>
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     <text><![CDATA[Inhalation and skin absorption are the main exposure routes in the workplace.]]></text>
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     <text><![CDATA[The study of the absorption, distribution, metabolism and elimination of substances is called toxicokinetics.]]></text>
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     <text><![CDATA[Absorption - substance passes through cell membranes in lungs, gastro-intestinal tract or skin.]]></text>
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     <text><![CDATA[Distribution - by the bloodstream and lymphatic system.]]></text>
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     <text><![CDATA[Hazardous substances can cause several types of toxic action on the body including:]]></text>
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    <action type="TEXTACTION" id="910" name="Asphyxiant - displac" hasCondition="False">
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     <text><![CDATA[Asphyxiant - displaces or interferes with oxygen utilisation]]></text>
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     <text><![CDATA[Mutagenic - damage to cellular genetic material causing hereditary effects]]></text>
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     <text><![CDATA[Teratogenic - damage to developing embryo/foetus]]></text>
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     <text><![CDATA[Toxic actions affecting the body's organs may be either localised or systemic.]]></text>
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     <text><![CDATA[Toxicity data is obtained from a variety of sources including epidemiology, animal and non-animal testing.]]></text>
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     <text><![CDATA[Epidemiology determines an association between a disease and its causative effects.  ]]></text>
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     <text><![CDATA[Animal testing observes how substances affect living organisms in humans or animals.]]></text>
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     <text><![CDATA[Non-animal testing is used to determine the effect of substances on cell cultures in laboratory glassware.]]></text>
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     <text><![CDATA[Toxicity data can be used to compare the relative toxicity between different substances.]]></text>
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     <text><![CDATA[The outcomes of toxicity testing are standardised, and classification schemes have been created to categorise the adverse effects of chemicals.]]></text>
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     <text><![CDATA[In Australia, the National Occupational Health and Safety Commission (NOHSC) provides a classification in the publication titled "Approved Criteria for Classifying Hazardous Substances".]]></text>
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     <text><![CDATA[Workers should always refer to the Material Safety Data Sheet to confirm whether a substance is hazardous.]]></text>
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     <text><![CDATA[The Material Safety Data Sheet (or MSDS) is the starting point for assessing the toxicity of substances used in the workplace and the precautions to be observed in their handling.]]></text>
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     <text><![CDATA[The manufacturer or importer of a substance is responsible for producing the MSDS.  ]]></text>
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     <text><![CDATA[Procedures for sampling are laid down in the National Code of Practice for the Control of Workplace Hazardous Substances.]]></text>
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     <text><![CDATA[It entails measurement of the concentration of a chemical in the blood or urine of people exposed, and is an indicator of the uptake of a substance.]]></text>
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     <text><![CDATA[The term 'Exposure Standard'  means an airborne concentration of a particular substance in the worker's breathing zone, which according to current knowledge, should not cause adverse health effects to nearly all workers.]]></text>
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     <text><![CDATA[a Time Weighted Average or TWA  concentration]]></text>
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